Diane McDougaldAssociate Professor, Singapore Centre for Environmental Life Sciences Engineering
- Singapore Centre for Environmental Life Sciences Engineering
About Diane McDougald
Asst. Prof. McDougald has made significant contributions to the fields of Vibrio biology, bacterial adaptation to stress and mechanisms of molecular control of these responses, cell-to-cell communication, biofilm formation and interactions of bacteria with higher eukaryotes. Her group’s major research interest is on the investigation of mechanisms of survival and persistence of pathogens in the environment, and what impact these mechanisms have on virulence and pathogenicity in the host. They investigate the evolutionary drivers and consequences of bacterial adaptation to stresses, including interactions with higher organisms. Broadly, they study the interactions of prokaryotes and eukaryotes using a number of model systems to investigate the impact of predation by protozoa on microbial communities and how evolution of grazing defences drives the evolution of pathogenicity in the environment. Predation is an important selection pressure that pathogens face in the environment, and as a result, pathogens may evolve phenotypes that not only increase their fitness in the environment, but may also increase their fitness in the human host. This research platform will allow her group to test key aspects of the Coincidental Selection Hypothesis, which states that the virulence of many opportunistic human pathogens may be an accidental by-product of selection for adaptations not related to human disease.