New On Nature.com: Synbiotic Approach Restores Intestinal Homeostasis And Prolongs Survival In Leukaemic Mice With Cachexia
Published online on November 23, 2015 by The ISME Journal, this article by Laure B Bindels, Audrey M Neyrinck, Patrice D Cani and Nathalie M Delzenne (Université Catholique de Louvain, Belgium), Sandrine P Claus and Caroline I Le Roy (University of Reading, UK), Corinne Grangette and Bruno Pot (Université Lille Nord de France, France) and Inés Martinez and Jens Walter (University of Alberta, Edmonton, Canada) is now available to view.
Cancer cachexia is a multifactorial syndrome that includes muscle wasting and inflammation. As gut microbes influence host immunity and metabolism, we investigated the role of the gut microbiota in the therapeutic management of cancer and associated cachexia. A community-wide analysis of the caecal microbiome in two mouse models of cancer cachexia (acute leukaemia or subcutaneous transplantation of colon cancer cells) identified common microbial signatures, including decreasedLactobacillus spp. and increased Enterobacteriaceae and Parabacteroides goldsteinii/ASF 519. Building on this information, we administered a synbiotic containing inulin-type fructans and live Lactobacillus reuteri 100-23 to leukaemic mice. This treatment restored the Lactobacillus population and reduced the Enterobacteriaceae levels. It also reduced hepatic cancer cell proliferation, muscle wasting and morbidity, and prolonged survival. Administration of the synbiotic was associated with restoration of the expression of antimicrobial proteins controlling intestinal barrier function and gut immunity markers, but did not impact the portal metabolomics imprinting of energy demand. In summary, this study provided evidence that the development of cancer outside the gut can impact intestinal homeostasis and the gut microbial ecosystem and that a synbiotic intervention, by targeting some alterations of the gut microbiota, confers benefits to the host, prolonging survival and reducing cancer proliferation and cachexia.