Human gut microbiome and xenobiotic metabolism

A nice Review has been published in Nature Reviews Mcrobiology on how the gut microbiome affects the efficacy and toxicity of xenobiotics, including drugs, dietary compounds and environmental toxins

Go to the profile of Magdalena Skipper
Apr 16, 2016
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The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

Nature Reviews Microbiology 14, 273–287 doi:10.1038/nrmicro.2016.17

Peter Spanogiannopoulous, Elizabeth N. Bess, Rachel N.Carmody and Peter J. Turnbaugh

Abstract

Although the importance of human genetic polymorphisms in therapeutic outcomes is well established, the role of our 'second genome' (the microbiome) has been largely overlooked. In this Review, we highlight recent studies that have shed light on the mechanisms that link the human gut microbiome to the efficacy and toxicity of xenobiotics, including drugs, dietary compounds and environmental toxins. Continued progress in this area could enable more precise tools for predicting patient responses and for the development of a new generation of therapeutics based on, or targeted at, the gut microbiome. Indeed, the admirable goal of precision medicine may require us to first understand the microbial pharmacists within.

http://www.nature.com/nrmicro/journal/v14/n5/full/...


Go to the profile of Magdalena Skipper

Magdalena Skipper

Editor in Chief, Nature, Nature Research, Springer Nature

I am a geneticist by training. Having done research using classical genetics and molecular biology in a variety of model organisms I left the bench to become an editor, first for Nature Reviews Genetics and then Nature. I have worked with the research community as an editor, in a variety of roles, for over 17 years

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