New paper in Science on Ecology of Microbiome

Interesting paper published by the group of Kevin Foster (Department of Zoology, University of Oxford, Oxford) that uses modeling approach to understand microbiome stability and found that microbial competition dampens cooperative networks and increases stability therefore benefiting the host.

Go to the profile of Akos T Kovacs
Nov 06, 2015
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The ecology of the microbiome: Networks, competition, and stability
Katharine Z. Coyte, Jonas Schluter, Kevin R. Foster

Science 350(6261): 663-666

ABSTRACT:

The human gut harbors a large and complex community of beneficial microbes that remain stable over long periods. This stability is considered critical for good health but is poorly understood. Here we develop a body of ecological theory to help us understand microbiome stability. Although cooperating networks of microbes can be efficient, we find that they are often unstable. Counterintuitively, this finding indicates that hosts can benefit from microbial competition when this competition dampens cooperative networks and increases stability. More generally, stability is promoted by limiting positive feedbacks and weakening ecological interactions. We have analyzed host mechanisms for maintaining stability—including immune suppression, spatial structuring, and feeding of community members—and support our key predictions with recent data.

http://www.sciencemag.org/content/350/6261/663

Go to the profile of Akos T Kovacs

Akos T Kovacs

Professor of Bacterial Physiology and Genetics, Technical University of Denmark, DTU Bioengineering

07/2017 - Professor of Bacterial Physiology and Genetics, DTU Denmark 10/2012-07/2017 Group Leader, FSU Jena, Germany 07/2005-07-2012 Post Doc, University Groningen, The Netherlands (w/ Oscar Kuipers) 09/2003-05/2005 Post Doc, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary (w/ Kornel Kovacs) 09/2000-09/2003 PhD fellow, University of Szeged, Hungary (w/ Kornel Kovacs) 09/1995-07/2000 BSc/MSc student, University of Szeged, Hungary

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