Review paper on Candida biofilms

Nice review in FEMS Yeast Research on polymicrobial Candida biofilms in the oral cavity

Go to the profile of Elisabeth M. Bik
Oct 30, 2015
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Polymicrobial Candida biofilms: friends and foe in the oral cavity

Lindsay E. O'Donnell, Emma Millhouse, Leighann Sherry, Ryan Kean, Jennifer Malcolm, Christopher J. Nile, Gordon Ramage

FEMS Yeast Research 2015, Volume 15, Issue 7

Abstract: The role of polymicrobial biofilm infections in medicine is becoming more apparent. Increasing number of microbiome studies and deep sequencing has enabled us to develop a greater understanding of how positive and negative microbial interactions influence disease outcomes. An environment where this is particularly pertinent is within the oral cavity, a rich and diverse ecosystem inhabited by both bacteria and yeasts, which collectively occupy and coexist within various niches as biofilm communities. Studies within this environment have however tended to be subject to extensive independent investigation, in the context of either polymicrobial bacterial communities or yeast biofilms, but rarely both together. It is clear however that they are not mutually exclusive. Therefore, this review aims to explore the influence of candidal populations on the composition of these complex aggregates and biofilm communities, to investigate their mechanistic interactions to understand how these impact clinical outcomes, and determine whether we can translate how this knowledge can be used to improve patient management.


Go to the profile of Elisabeth M. Bik

Elisabeth M. Bik

Science Editor, uBiome

After receiving my PhD at Utrecht University in The Netherlands, I worked at the Dutch National Institute for Health and the St. Antonius Hospital in Nieuwegein. From 2001-2016 I worked in the laboratory of David Relman at Stanford University, where I have worked on the characterization of human oral, gastric, and intestinal microbiotas, and that of marine mammals. In 2016 I joined uBiome where we allow citizen scientists to sequence their microbiome. I also run Microbiome Digest, www.microbiomedigest.com, an almost daily compilation of scientific papers in the rapidly growing microbiome field, tweet on Twitter as @MicrobiomDigest, and scan published papers for image manipulation.

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