The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease

This article from Clinical and Translational Gastroenterology, describes the fine balance in the mutual relationship between the intestinal microbiota and its mammalian host. It is thought that disruptions in this fine balance contribute/account for the pathogenesis of many diseases.

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Jul 02, 2015
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There is a fine balance in the mutual relationship between the intestinal microbiota and its mammalian host. It is thought that disruptions in this fine balance contribute/account for the pathogenesis of many diseases. Recently, the significance of the relationship between gut microbiota and its mammalian host in the pathogenesis of obesity and the metabolic syndrome has been demonstrated. Emerging data has linked intestinal dysbiosis to several gastrointestinal diseases including inflammatory bowel disease, irritable bowel syndrome, nonalcoholic fatty liver disease, and gastrointestinal malignancy. This article is intended to review the role of gut microbiota maintenance/alterations of gut microbiota as a significant factor as a significant factor discriminating between health and common diseases. Based on current available data, the role of microbial manipulation in disease management remains to be further defined and a focus for further clinical investigation.

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Go to the profile of Martin Delahunty

Martin Delahunty

Global Director, Nature Partner Journals, Nature Research

Working within Nature Research's Open Research Group, I am Global Director for Nature Partner Journals based in London. I have responsibility across five global office locations to develop Nature Partner Journals, a new series of online-only, open access journals, published in collaboration with world-renowned partners. Launched in April 2014, the portfolio now includes 14 titles including 'npj Biofilms and Microbiomes'. I have a Degree in Natural Sciences specializing in Microbiology from Trinity College Dublin and a Masters in Business Administration from The Open University. Within the broader medical publications community, I serve as Secretary and Trustee for the International Society for Medical Publication Professionals.

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