The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells In Vitro
New research from Ghent University looks at bacteria and metastasis in breast cancer.
The human microbiome comprises a huge number of bacteria cells, some of which may play a role in cancer progression. Bacteria communicate with each other using signalling molecules in a process called "quorum sensing". Recently, a team of researchers from Ghent University in Belgium found that quorum sensing molecules can promote tumour cell invasion and blood vessel formation in breast cancer cell line experiments. Their results show that bacteria can potentially influence tumour metastasis in breast cancer.
Bart De Spiegeleer , Frederick Verbeke, Matthias D’Hondt, An Hendrix, Christophe Van De Wiele, Christian Burvenich, Kathelijne Peremans, Olivier De Wever, Marc Bracke, Evelien Wynendaele. The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells In Vitro. PLOS ONE 2015 DOI: 10.1371/journal.pone.0119471